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Long Noncoding RNAs and Stress Response in the Nucleolus.
Sergei A Pirogov1, Vladimir A Gvozdev2, Mikhail S Klenov3
1Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., 123182 Moscow, Russia.
Cells
|July 5, 2019
Summary
Long noncoding RNAs (lncRNAs) in the nucleolus regulate cellular responses to stress by controlling ribosomal RNA synthesis and protein sequestration. These nucleolar lncRNAs also influence cell states like quiescence and cancer.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Long noncoding RNAs (lncRNAs) are key regulators of cellular processes.
- The nucleolus, the ribosome production center, harbors specific lncRNAs.
- The role of nucleolar lncRNAs in stress response and cell state regulation is emerging.
Purpose of the Study:
- To review the diverse functions of nucleolar long noncoding RNAs.
- To highlight the involvement of nucleolar lncRNAs in environmental stress adaptation.
- To discuss the role of nucleolar lncRNAs in cell states such as quiescence and cancer.
Main Methods:
- Literature review of recent findings on nucleolar lncRNAs.
- Analysis of lncRNA functions in response to environmental stressors.
- Examination of lncRNA involvement in nucleolar protein sequestration and rRNA synthesis.
Main Results:
- Nucleolar lncRNAs are crucial for adapting to environmental stressors.
- These lncRNAs induce cessation of ribosomal RNA synthesis.
- They also mediate the massive sequestration of proteins within the nucleolus for stress adaptation.
- Specific nucleolar lncRNAs regulate cell states like quiescence and cancer.
Conclusions:
- Long noncoding RNAs are multifunctional regulators of nucleolar activities.
- Nucleolar lncRNAs play a significant role in cellular responses to various physiological conditions and environmental stressors.
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