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Complete Genome Sequence of GD487, a High-Virulence Strain of Human-Associated ST398 Methicillin-Susceptible

Jo-Ann McClure1, Steven M Shideler2, Kunyan Zhang3,4,2,5,6

  • 1Centre for Antimicrobial Resistance, Alberta Health Services/Alberta Public Laboratories/University of Calgary, Calgary, Alberta, Canada.

Microbiology Resource Announcements
|July 5, 2019
PubMed

Insights

Multilocus sequence type 398 (ST398) methicillin-susceptible Staphylococcus aureus (MSSA) shows increased human pathogenicity. This study sequences a high-virulence ST398 MSSA strain to investigate the genetic basis of its augmented virulence.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Methicillin-susceptible Staphylococcus aureus (MSSA) strains belonging to multilocus sequence type 398 (ST398) have demonstrated increased pathogenicity in human infections.
  • However, the extent to which virulence varies among different ST398 strains remains unclear.

Purpose of the Study:

  • To investigate the genomic basis of high virulence in a specific ST398 MSSA strain.
  • To explore potential genetic factors contributing to the augmented pathogenicity of ST398 MSSA in humans.

Main Methods:

  • Whole-genome sequencing of the high-virulence ST398 MSSA strain GD487.
  • Bioinformatic analysis of the genome sequence to identify virulence-associated genes and genomic features.

Main Results:

  • The genome sequence of the high-virulence ST398 MSSA strain GD487 was successfully obtained.
  • Analysis is ongoing to identify specific genetic determinants responsible for the enhanced virulence of this strain.

Conclusions:

  • The genomic data from strain GD487 provides a foundation for understanding ST398 MSSA virulence.
  • Further research will elucidate the specific genetic mechanisms underlying the augmented pathogenicity of ST398 strains.

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