Association between PTEN and clinical-pathological features of osteosarcoma

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Previous studies suggest phosphatase and tensin homolog deleted on chromosome ten (PTEN) has prognostic value in osteosarcoma (OS).
• Inconsistencies exist in current research regarding PTEN's role in OS.
• A comprehensive analysis is needed to clarify PTEN's association with clinicopathological features and prognosis in OS.

Purpose of the Study:

• To conduct a meta-analysis investigating the relationship between PTEN positive expression and clinicopathological features in osteosarcoma (OS).
• To evaluate the prognostic significance of PTEN positive expression in osteosarcoma patients.

Main Methods:

• Systematic literature search of multiple databases (PubMed, Embase, Springer, Web of Knowledge, Cochrane, CNKI, Wanfang, VIP, CBM) for studies published before November 28, 2018.
• Inclusion of 13 studies involving 580 osteosarcoma patients.
• Meta-analysis using pooled odds ratios (OR) and 95% confidence intervals (CIs) to assess outcomes.

Main Results:

• PTEN positive expression was significantly associated with male patients (OR = 1.57) and high differentiation in OS (OR = 2.33).
• Positive PTEN expression was linked to a lack of metastasis (OR = 5.69).
• PTEN positive expression predicted a higher 5-year survival rate in OS patients (OR = 8.73).

Conclusions:

• Positive PTEN expression is significantly associated with favorable clinicopathological features in osteosarcoma, including male gender and high differentiation.
• PTEN positive expression serves as a potential biomarker for predicting no metastasis and improved overall survival in osteosarcoma.
• This meta-analysis supports the prognostic value of PTEN in osteosarcoma, highlighting its potential clinical utility.