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Related Concept Videos

Storage01:23

Storage

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A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
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Sugars as Energy Storage Molecules01:10

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Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
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ATP Energy Storage and Release

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ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
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Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Nanopore DNA Sequencing for Metagenomic Soil Analysis
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DNA assembly for nanopore data storage readout.

Randolph Lopez1,2, Yuan-Jyue Chen3, Siena Dumas Ang3

  • 1Department of Bioengineering, University of Washington, Seattle, WA, 98105, USA.

Nature Communications
|July 5, 2019
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Summary
This summary is machine-generated.

Researchers decoded 1.67 megabytes of data stored in synthetic DNA using portable nanopore sequencing. A novel assembly strategy boosts sequencing throughput for DNA data storage and small DNA amplicon applications.

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Area of Science:

  • Biotechnology
  • Bioinformatics
  • Molecular Biology

Background:

  • Synthetic DNA offers high-density, durable digital data storage.
  • Current DNA sequencing methods are slow, expensive, and laborious, hindering DNA data storage applications.

Purpose of the Study:

  • To demonstrate the feasibility of decoding large amounts of data from synthetic DNA using portable nanopore sequencing.
  • To develop and validate an efficient DNA assembly strategy for enhanced nanopore sequencing throughput.

Main Methods:

  • Storing 1.67 megabytes of digital information in short synthetic DNA fragments.
  • Utilizing a portable nanopore sequencing platform for DNA readout.
  • Designing and implementing a novel DNA assembly strategy to improve sequencing efficiency.

Main Results:

  • Successful decoding of 1.67 megabytes of data from synthetic DNA.
  • Significant increase in nanopore sequencing throughput achieved with the new assembly strategy.
  • Demonstrated the generalizability of the assembly strategy for sequencing small DNA amplicons.

Conclusions:

  • Portable nanopore sequencing is a viable method for reading data from synthetic DNA storage.
  • The developed DNA assembly strategy enhances nanopore sequencing efficiency for DNA data storage.
  • The strategy is applicable to various applications requiring nanopore sequencing of small DNA fragments.