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68Ga-NOTA-Aca-BBN(7-14) PET imaging of GRPR in children with optic pathway glioma

Jingjing Zhang1,2,3, Yongji Tian4, Deling Li5

  • 1Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

European Journal of Nuclear Medicine and Molecular Imaging
|July 5, 2019
PubMed

Insights

Gastrin-releasing peptide receptor (GRPR)-targeted PET imaging effectively detected optic pathway gliomas (OPGs) in children. This GRPR-targeted PET/MRI approach shows promise for guiding surgery and potential future therapies for OPGs.

Area of Science:

  • Pediatric Neuro-oncology
  • Molecular Imaging
  • Radiopharmaceuticals

Background:

  • Optic pathway glioma (OPG) presents management challenges in pediatric neuro-oncology due to its location and patient age.
  • Accurate tumor detection and localization are crucial for effective OPG treatment planning.

Purpose of the Study:

  • To assess the feasibility of gastrin-releasing peptide receptor (GRPR)-targeted positron emission tomography (PET) imaging in children with OPG.
  • To evaluate the application of a PET/MRI imaging-guided surgery navigation platform for OPG management.

Main Methods:

  • Eight children with suspected OPG underwent PET/CT or PET/MRI using 68Ga-NOTA-Aca-BBN(7-14).
  • Comparison with 18F-FDG PET was performed in four patients.
  • All patients underwent surgical resection, and imaging was fused with a navigation platform.

Main Results:

  • 100% of OPG lesions showed prominent 68Ga-NOTA-Aca-BBN(7-14) uptake with excellent contrast.
  • GRPR-targeted PET demonstrated significantly higher tumor-to-background ratios than 18F-FDG PET.
  • PET/MRI facilitated tumor delineation for surgical planning, and uptake correlated with GRPR expression.

Conclusions:

  • 68Ga-NOTA-Aca-BBN(7-14) PET is feasible for OPG detection and localization in children.
  • GRPR-targeted PET/MRI can aid surgical planning for symptomatic OPG patients.
  • GRPR-targeted PET holds potential for guiding future targeted therapies in OPG.
Abstract

Keywords:
68Ga-NOTA-Aca-BBN(7-14)Gastrin-releasing peptide receptor (GRPR)Optic pathway glioma (OPG)PETPET/MRIPaediatric neuro-oncology

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