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The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics
Published on: October 21, 2013
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Energy-Mediated Machinery Drives Cellular Mechanical Allostasis
Qianbin Wang1, Weiyi Qian1, Xiaoyu Xu1
1Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.
Advanced Materials (Deerfield Beach, Fla.)
|July 5, 2019
Summary
Cellular allostasis maintains stability through mechanical and energy changes, involving a biphasic process of adaptation and relaxation. This study reveals the biophysical origins of cellular mechanical allostasis.
Area of Science:
- Biophysics
- Cell Biology
- Mechanobiology
Background:
- Allostasis is crucial for organismal stability against stress.
- Understanding cellular-level allostasis remains incomplete.
- Mechanisms involve physiological and behavioral adaptations.
Purpose of the Study:
- To investigate cellular allostasis at the subcellular level.
- To elucidate the role of mechanics and energy in cellular adaptation.
- To explore the biophysical origins of cellular mechanical allostasis.
Main Methods:
- Utilized an integrated micromechanical tool for controlled stress application.
- Simultaneously measured dynamic subcellular mechanics.
- Observed individual cell responses to mechanical stimulation.
Main Results:
- Cellular allostasis occurs via a biphasic process: mechanoadaptation and decay.
- Cells achieve stability through a balance of subcellular energy and mechanics.
- Transient stimulation triggers an allostatic state maximizing energy, followed by relaxation.
Conclusions:
- Cellular allostasis is driven by energy maximization and overcoming mechanical barriers.
- Force-sensitive cytoskeleton equilibrium is critical for cellular allostasis.
- Provides subcellular insights into diseases and aging related to mechanical allostasis.
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