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Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
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Intensity modulated proton therapy plan generation in under ten seconds.

Michael Matter1,2, Lena Nenoff1,2, Gabriel Meier1

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Generating intensity modulated proton therapy (IMPT) plans rapidly using graphical processing units (GPUs) enables faster adaptive treatments. This approach significantly reduces computation time without compromising plan quality for IMPT.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Imaging

Background:

  • Intensity modulated proton therapy (IMPT) plan calculation is time-consuming, hindering efficient treatment planning and adaptive therapy.
  • Current computation times for IMPT plan generation are problematic, despite proposed dose restoration methods for adaptive treatments.

Purpose of the Study:

  • To significantly reduce IMPT plan generation times.
  • To enable efficient sampling of the IMPT solution space and facilitate online adaptive treatments.

Main Methods:

  • Developed dedicated graphical processing unit (GPU) kernels for in-house, clinically validated dose and optimization algorithms.
  • Integrated kernels into a system performing all treatment plan generation steps.

Main Results:

  • Generated complete IMPT plans in 5-10 seconds for typical cases and under 25 seconds for large volumes using a single GPU.
  • Achieved comparable or improved plan quality, with target coverage/homogeneity improving up to 6% and no significant worsening of organ-at-risk parameters.

Conclusions:

  • Fast IMPT plan generation using validated algorithms and GPUs is a promising approach for daily adaptive proton therapy.
  • This method supports automated or highly interactive treatment planning.