H2FPEF Score as a Prognostic Value in HFpEF Patients

Area of Science:

• Cardiology
• Heart Failure Research
• Predictive Biomarkers

Background:

• Heart failure with preserved ejection fraction (HFpEF) poses diagnostic challenges.
• The H2FPEF score is a recognized diagnostic tool for HFpEF.
• Predictive value of the H2FPEF score for adverse events in HFpEF requires further investigation.

Purpose of the Study:

• To evaluate the H2FPEF score's utility in predicting subsequent cardiovascular and heart failure-related events in HFpEF patients.
• To assess the correlation between H2FPEF score strata and event incidence.
• To determine the independent predictive capability of the H2FPEF score.

Main Methods:

• Retrospective, single-center observational study of 404 HFpEF patients.
• Calculation of H2FPEF scores and stratification into low, intermediate, and high-score groups.
• 50-month follow-up for composite cardiovascular/cerebrovascular events and HF-related events.

Main Results:

• Higher H2FPEF scores correlated with significantly increased incidence of cardiovascular/cerebrovascular events (P=0.005) and HF-related events (P<0.001).
• The H2FPEF score was an independent predictor of both cardiovascular (HR 1.179) and HF-related events (HR 1.288).
• ROC analysis indicated significant predictive power for cardiovascular events (AUC 0.626) and HF-related events (AUC 0.680), with a cutoff score of 5.5.

Conclusions:

• The H2FPEF score demonstrates potential as a valuable tool for predicting cardiovascular and heart failure events in HFpEF patients.
• Risk stratification using the H2FPEF score can aid in managing HFpEF.
• Further validation in diverse cohorts is warranted.