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Updated: Jan 22, 2026
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Immunohistochemistry and Multiple Labeling with Antibodies from the Same Host Species to Study Adult Hippocampal Neurogenesis
Published on: April 22, 2015
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Cadmium Exposure Impairs Adult Hippocampal Neurogenesis
Hao Wang1, Glen M Abel1, Daniel R Storm2
1Toxicology Program, Department of Environmental and Occupational Health Sciences.
Summary
Cadmium exposure harms adult hippocampal neurogenesis, a process crucial for memory. This environmental pollutant induces cell death and hinders new neuron formation, potentially explaining memory deficits.
Area of Science:
- Neuroscience
- Environmental Toxicology
- Cell Biology
Background:
- Cadmium (Cd) is a global environmental pollutant with neurotoxic potential.
- Cd exposure impairs hippocampus-dependent learning and memory in mice.
- Mechanisms underlying Cd-induced neurotoxicity, particularly on adult neurogenesis, are not fully understood.
Purpose of the Study:
- To investigate if Cadmium inhibits adult hippocampal neurogenesis.
- To identify the signaling pathways involved in Cadmium's neurotoxic effects on adult neural progenitor cells (aNPCs).
Main Methods:
- In vitro: Primary cultured aNPCs from the subgranular zone (SGZ) were exposed to Cadmium.
- In vivo: Adult mice were exposed to Cadmium in drinking water for 13 weeks.
- Assessed apoptosis, proliferation, neuronal differentiation, and cell survival in the dentate gyrus (DG).
Main Results:
- Cadmium induced apoptosis, inhibited proliferation, and impaired neuronal differentiation in cultured aNPCs.
- Cadmium activated c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase pathways.
- In vivo, Cadmium reduced the number of adult-born cells in the DG and impaired their differentiation.
Conclusions:
- Cadmium exposure impairs adult hippocampal neurogenesis both in vitro and in vivo.
- This impairment of neurogenesis may underlie Cadmium-mediated deficits in learning and memory.
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