Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

835
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
835
Initiation of Translation02:33

Initiation of Translation

38.4K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
38.4K
Initiation of Translation02:33

Initiation of Translation

8.0K
8.0K
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

281
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
281
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

229
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
229
Transcription Initiation01:47

Transcription Initiation

20.5K
Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
20.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population arterial input function measured from low dose breast ultrafast dynamic contrast enhanced MRI and fitted with a new mathematic model.

Magnetic resonance imaging·2026
Same author

Automated Cluster-based Quantitative Analysis of Ultrafast DCE MRI for Differential Breast DCIS Grading.

Radiology. Imaging cancer·2026
Same author

K-means clustering-based analysis of quantitative ultrafast DCE-MRI for predicting breast cancer response to neoadjuvant chemotherapy.

Journal of applied clinical medical physics·2025
Same author

Ultrafast breast DCE-MRI: comparative analysis of semi-quantitative and pharmacokinetic parameters with gadoterate meglumine versus gadobutrol in malignant lesions and background parenchymal enhancement.

Quantitative imaging in medicine and surgery·2025
Same author

Clinical application of gadoterate meglumine in abbreviated dynamic contrast-enhanced magnetic resonance imaging of the breast with ultrafast imaging: a single-center retrospective study.

Quantitative imaging in medicine and surgery·2025
Same author

A Translational Research Leveraging Diagnostic Accuracy of Innovations in MRI as a Model for Early Breast Cancer Detection in Uganda.

Technology in cancer research & treatment·2025

Related Experiment Video

Updated: Jan 22, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.4K

Low-dose imaging technique (LITE) MRI: initial experience in breast imaging.

Federico Pineda1, Deepa Sheth1, Hiroyuki Abe1

  • 1Department of Radiology, The University of Chicago, Chicago, IL.

The British Journal of Radiology
|July 5, 2019
PubMed
Summary

Low-dose dynamic contrast-enhanced breast MRI (LITE MRI) shows potential to detect breast lesions as effectively as standard doses. This approach may improve sensitivity to contrast dynamics, potentially enhancing screening compliance and patient safety.

More Related Videos

Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI
08:36

Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI

Published on: March 6, 2014

19.6K
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.7K

Related Experiment Videos

Last Updated: Jan 22, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.4K
Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI
08:36

Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI

Published on: March 6, 2014

19.6K
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.7K

Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Dynamic contrast-enhanced MRI (DCE-MRI) is a key tool for breast lesion detection.
  • Standard DCE-MRI protocols utilize a full dose of contrast media.
  • Optimizing contrast dose is crucial for patient safety and cost-effectiveness.

Purpose of the Study:

  • To compare a low-dose dynamic contrast-enhanced breast MRI protocol (LITE MRI) against standard-dosage DCE-MRI.
  • To evaluate the efficacy of LITE MRI in detecting enhancing breast lesions.
  • To assess the impact of reduced contrast dose on enhancement kinetics and image quality.

Main Methods:

  • Eight female patients with 10 fibroadenoma-compatible lesions underwent dual-dose DCE-MRI.
  • A low dose (15% of standard) was administered initially, followed by the remaining 85% after 10 minutes.
  • Quantitative analysis included enhancement kinetic parameters, lesion conspicuity, and signal-to-noise ratio.

Main Results:

  • All nine enhancing lesions were visualized with both low-dose and standard-dose protocols.
  • Lesion conspicuity and enhancement rate were higher in LITE MRI images (ratios 1.5 and 1.2, respectively).
  • Standard-dose images showed higher upper limit of enhancement and SNR, but less than expected based on dose ratio.

Conclusions:

  • LITE MRI demonstrates potential to match standard DCE-MRI for detecting enhancing breast lesions.
  • Reduced contrast doses may enhance sensitivity to contrast media dynamics.
  • LITE MRI could improve breast cancer screening compliance and long-term patient safety.