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Peptoniphilus asaccharolyticus - Commensal, pathogen or synergist? Two case reports on invasive Peptoniphilus

Eloise Müller-Schulte1, Kirstin C Heimann1, Wolfgang Treder1

  • 1Centre of Excellence for Microbiology and Hygiene, St. Franziskus-Hospital, Münster, Germany.

Anaerobe
|July 5, 2019
PubMed

Insights

Peptoniphilus asaccharolyticus, a gram-positive anaerobic coccus, can cause severe bone and joint infections. This study highlights its pathogenic potential and synergistic interactions with other bacteria.

Area of Science:

  • Microbiology
  • Infectious Diseases

Background:

  • Peptoniphilus asaccharolyticus (GPAC) are typically commensals or found in polymicrobial infections.
  • The pathogenic role of P. asaccharolyticus in severe invasive infections is not well understood.

Observation:

  • This report details two cases of P. asaccharolyticus-associated bone and joint infections.
  • A literature review was conducted to supplement the case studies.

Findings:

  • P. asaccharolyticus can act as a pathogen in severe mono-infections.
  • Evidence suggests synergistic interactions between P. asaccharolyticus and aerobic bacteria in infections.

Implications:

  • These findings expand our understanding of P. asaccharolyticus pathogenicity.
  • Further research into virulence factors and treatment strategies for P. asaccharolyticus infections is warranted.
Keywords:
AnaerobicBloodstream infectionBone and joint infectionImmunosuppression

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