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Updated: Jan 22, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
Five new polyphenolic derivatives with antimicrobial activities from the root barks of Periploca sepium
Wei Zhao1, Hai-Li Chen2, Liu Hong1
1Research &Development Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650201, China.
Abstract:
Five new polyphenolic derivatives, sepiumols A-E (1-5), were isolated from the root barks of Periploca sepium. Their structures were elucidated by interpretation of NMR spectroscopic and mass spectrometric data. Compounds 1, 3 and 5 were found to exhibit significant antifungal activity, particularly for 3 with the remarkable activity against Gibberella saubinetii and Alternaria longipes with MIC values of 1.56 and 3.13 μg/mL (ketoconazole: 0.78 μg/mL), respectively. In addition, compounds 1, 3 and 5 also displayed significant antibacterial activity against methicillin-resistant Staphylococcus aureu with MIC values of 12.50-25 μg/mL (ciprofloxacin: 0.78 μg/mL).
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