Circadian ontogeny through the lens of nonparametric variables of actigraphy

Studies focusing on human rhythmicity show that human circadian rhythm suffers constant changes across lifespan. Changes in rest-activity patterns can be studied through nonparametric variables of actigraphy: L5 (an individual's least active 5 h), M10 (an individual's most active 10 h) and RA (relative amplitude of the rest-activity rhythm). The variable RA is the normalized difference between L5 and M10 - the higher the RA, the greater the difference between these two variables. This study used the data bank of the Human Chronobiology Laboratory of Federal University of Paraná (Brazil). It analyzed actimetric data of 93 children between 4 and 11 years of age in their naturalistic context in order to describe the development of nonparametric variables. Correlation between age and L5 was significantly negative (rho = - 0.29, p = 0.004), while correlation between age and RA was significantly positive (rho = 0.31, p = 0.003). The variables M10, sL5 (start of L5) and sM10 (start of M10) did not show significant correlation to age. Furthermore, there were no statistical differences between genders. The population of this study, healthy children, has been poorly assessed by similar literature. Through our results, we have demonstrated that, as children age, L5 significantly decreases, which reflects a smaller fragmentation of circadian rhythm. As an expected consequence, RA significantly increases. In other words, these nonparametric variables of actimetry successfully demonstrate that children tend to reduce nocturnal activity as they age, a phenomenon that reflects the ongoing consolidation of circadian rhythm.