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Updated: Jan 22, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Device closure of diverse layout of multi-hole secundum atrial septal defect: different techniques and long-term
Zeeshan Farhaj1, Li Hongxin2, Guo Wenbin3
1Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No 324 Jingwu Road, Jinan, 250021, China.
Insights
This study introduces a new classification for multi-hole secundum atrial septal defects (MHASD) to guide tailored occlusion techniques. The classification improved procedural efficiency and successful closure rates for these complex heart defects.
Area of Science:
- Cardiology
- Medical Devices
- Surgical Techniques
Background:
- Standardized classifications and occlusion techniques for multi-hole secundum atrial septal defects (MHASD) lack consensus.
- MHASDs present with variable cribriform or isolated layouts and inter-defects distances.
Purpose of the Study:
- To present an experience-based classification for MHASDs.
- To evaluate the outcomes of two distinct occlusion approaches based on this new classification.
Main Methods:
- Retrospective analysis of 150 MHASD patients from 1320 undergoing atrial septal defect occlusion.
- Categorization of MHASDs into four types (A, B, C, D) for guided occlusion via transesophageal echocardiography.
- Comparison of peratrial (n=122) and percutaneous (n=28) approaches, with specific device strategies for each type.
Main Results:
- Successful occlusion achieved in all 150 patients.
- Single-device occlusion was more frequent in Type A, while double-device was more applicable to Type B (p<0.01).
- Patent foramen ovale devices were effective for Type C and D. Procedural times were shorter for Type A and peratrial approaches.
Conclusions:
- A novel MHASD classification aids in selecting appropriate techniques and devices.
- This approach facilitates better occlusion outcomes for complex atrial septal defects.
Background:
There are no unanimous reports on different layouts and classifications of multi-hole secundum atrial septal defects (MHASD) and subsequent standardized occlusion techniques. The MHASD can be isolated or cribriform with variable inter-defects distance. In this retrospective study, experience-based classification and two approaches-based occlusion results are presented.
Methods:
We retrospectively collected and analyzed data of 150 MHASD patients from 1320 patients who underwent atrial septal defect occlusion in our institute. The MHASD patients were categorized into 4 types; type A, B, C and D and occluded under exclusive transesophageal echocardiographic guidance. According to different types, 122 patients were occluded using peratrial approach and 28 patients via percutaneous approach. In type A, single device implantation is performed to occlude the large hole and squeeze the small one. For type B single or double-device deployment was performed depending on an inter-defects distance. In type C and D, a patent foramen-ovale (PF) device was selectively positioned to the central defect to occlude the central defect and cover the peripheral ones. In peratrial approach, 8 patients underwent inter-defects septal puncture technique to achieve single-device occlusion. The intracardiac manipulation time, procedural time, double device deployment, redeployment rate, residual shunt, and proportions were analyzed between (and within peratrial technique) two techniques.
Results:
Successful occlusion was achieved in all 150 patients. Single device occlusion was applied in 78/84 type A and 22/37 type B patients (p < 0.05). Double device occlusion was more applicable to type B than A patients (p < 0.01). Sixteen of 21 type C and all type D patients used PF device for a satisfactory occlusion. Redeployment of the device occurred frequently in type B patients than A (p < 0.01). The intracardiac manipulation time and procedural time were shorter in type A than B (p < 0.05). The intracardiac manipulation time was also shortened in type A peratrial than type A percutaneous group (p < 0.05). Complete occlusion rate for all patients at discharge was 70% and rose to 82% at 1 year follow up.
Conclusions:
The diverse layouts and classification of MHASDs can help to choose different techniques and proper devices of different kinds to achieve better occlusion results.
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