Related Experiment Video

Updated: Jan 22, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.1K

The effect of cardiac shock wave therapy on myocardial function and perfusion in the randomized, triple-blind,

Jelena Čelutkienė1, Greta Burneikaitė2, Evgeny Shkolnik3

  • 1Institute of Clinical Medicine of the Faculty of Medicine of Vilnius University, Santariskiu St. 2, 08661, Vilnius, Lithuania. jelena.celutkiene@santa.lt.

Cardiovascular Ultrasound
|July 6, 2019
PubMed

Insights

Cardiac shock wave therapy (CSWT) improved regional myocardial contractility and reduced perfusion defects in patients with stable angina. This imaging study demonstrated CSWT

Area of Science:

  • Cardiology
  • Medical Imaging
  • Therapeutic Technologies

Background:

  • Previous studies indicated neutral effects of cardiac shock wave therapy (CSWT) on exercise tolerance in stable angina.
  • Limited data exists on CSWT's impact on myocardial contractility and perfusion.
  • This study investigated CSWT's efficacy in ameliorating myocardial ischemia using advanced imaging techniques.

Purpose of the Study:

  • To evaluate the effect of CSWT on global and regional myocardial contractility.
  • To assess CSWT's capacity to improve myocardial perfusion.
  • To determine CSWT's effectiveness in reducing stress-induced myocardial ischemia.

Main Methods:

  • A prospective, randomized, triple-blind, sham-controlled study involving 72 patients with stable angina.
  • Patients received either optimal medical therapy (OMT) + CSWT or OMT + sham procedure.
  • Dobutamine stress echocardiography (DSE) and single-photon emission computed tomography (SPECT) were used to assess myocardial function and perfusion at baseline, 3 months, and 6 months.

Main Results:

  • CSWT significantly improved regional myocardial contractility at 3 months, as indicated by wall motion score index (WMSI) during DSE.
  • SPECT revealed a significant reduction in inducible ischemia in the CSWT group compared to the sham group at 6 months.
  • The reduction in perfusion defects (summed difference score, SDS) was significant in the CSWT group post-treatment.

Conclusions:

  • Cardiac shock wave therapy demonstrated a capacity to reduce stress-induced myocardial ischemia.
  • Improvements were observed in both regional myocardial contractility and perfusion defects.
  • CSWT shows potential as an adjunctive therapy for managing myocardial ischemia in stable angina.
Abstract

Keywords:
Cardiac shock wave therapyCoronary artery diseaseDobutamine stress echocardiographyMyocardial perfusionSingle photon emission computed tomographyStable angina

More Related Videos

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.6K
Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.6K

Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.4K
Shock Waves01:16

Shock Waves

While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
2.5K
Graphing the Wave Function01:13

Graphing the Wave Function

Consider the wave equation for a sinusoidal wave moving in the positive x-direction. The wave equation is a function of both position and time. From the wave equation, two different graphs can be plotted.
3.0K
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
3.8K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
241
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
1.2K