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Updated: Jan 22, 2026

GM-Free Generation of Blood-Derived Neuronal Cells
Published on: February 13, 2021
Amnion-derived cells as a reliable resource for next-generation regenerative medicine
Akihiro Umezawa1, Akihiro Hasegawa2, Momoko Inoue2
1Department of Reproductive Biology, National Center for Child Health and Development, Tokyo, 157-8535, Japan.
Abstract:
The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine. Endothelial cells are obtained from large arteries and veins in the amniotic membrane as well as the umbilical cord. The amnion-derived cells exhibit transdifferentiation capabilities, including chondrogenesis and cardiomyogenesis, by introduction of transcription factors, in addition to their original and potential phenotypes. The amnion is also a source for production of induced pluripotent stem cells (AM-iPSCs). The AM-iPSCs exhibit stable phenotypes, such as multipotency and immortality, and a unique gene expression pattern. Through the use of amnion-derived cells, as well as other placenta-derived cells, preclinical proof of concept has been achieved in a mouse model of muscular dystrophy.
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