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Prednisolone treatment induced temporary factor IX normalization in mild hemophilia B who required an epidural

M Carrette1, G Feugray1, P Chamouni2

  • 1Rouen University Hospital, Vascular Hemostasis Unit, F 76000 Rouen, France.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|July 6, 2019
PubMed

A 31-year-old man with mild hemophilia B developed a herniated disc treated with prednisolone for back pain. Surprisingly, hemostasis result tests performed before epidural infiltration were a normal activated partial thrombin time at 36.1 s. (normal range 27.9-37.7 s.) and factor IX (FIX) level 76% (normal range>70%), 13 days after prednisolone introduction. After a second control with a normal FIX level and a second genetic confirmation of hemophilia, no FIX concentrates was administered to perform the infiltration, which occurred without hemorrhagic complication. This new case of FIX normalization showed the necessity to have a perfect knowledge of patient's treatment to avoid misdiagnosis and a temporary normal hemostasis permit to perform epidural infiltration without replacement therapy.

Keywords:
Epidural infiltrationFactor IX normalizationFresh frozen plasmaHemophiliaHerniated disc

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