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Hypothalamic regulation of thyrotropin biosynthesis and secretion
E C Ridgway1, S Greenspan, M Shupnik
1University of Colorado Health Sciences Center, Denver.
Hormone and Metabolic Research. Supplement Series
|January 1, 1987
Summary
The hypothalamus regulates thyroid-stimulating hormone (TSH) secretion and gene expression, with nocturnal TSH release influenced by pulse frequency and amplitude. Further research will clarify the hypothalamus
Area of Science:
- Neuroendocrinology
- Molecular Biology
- Physiology
Background:
- Thyroid-stimulating hormone (TSH) is crucial for thyroid function.
- The regulation of TSH secretion is complex and involves central nervous system control.
Purpose of the Study:
- To investigate the role of the hypothalamus in regulating TSH secretion and TSH subunit gene expression.
- To analyze the effects of thyrotropin-releasing hormone (TRH) and dopamine on TSH subunit gene transcription.
Main Methods:
- Clinical studies in humans.
- In vitro cell culture studies.
Main Results:
- Clinical studies revealed pulsatile TSH secretion with significant circadian variation.
- The nocturnal rise in TSH is dependent on pulse frequency and amplitude.
- In vitro studies showed TRH stimulates and dopamine depresses TSH subunit gene transcription.
Conclusions:
- The hypothalamus plays a significant role in regulating TSH biosynthesis and secretion.
- Further human and cell culture studies are needed to fully elucidate hypothalamic control over TSH.