Hypothalamic regulation of thyrotropin biosynthesis and secretion
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E C Ridgway1, S Greenspan, M Shupnik
1University of Colorado Health Sciences Center, Denver.
Abstract:
These clinical studies in humans and the in vitro cell culture studies suggest that the hypothalamus plays an important role in regulating TSH secretion and TSH subunit gene expression. The clinical studies have demonstrated a pulsatile secretion of TSH with a significant circadian variation. The nocturnal rise of TSH is pulse frequency and amplitude dependent. The effects of TRH and dopamine were analyzed in in vitro cell cultures and shown to stimulate and depress TSH subunit gene transcription, respectively. Further studies in humans and cell culture will further delineate the important role of the hypothalamus in regulating TSH biosynthesis and secretion.