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Isolation and Transplantation of Hematopoietic Stem Cells HSCs
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Technical note: accuracy and precision in stereotactic stem cell transplantation.

David Satzer1, Peter C Warnke2

  • 1Department of Neurosurgery, University of Chicago, 5841 S. Maryland Avenue, MC 3026, Chicago, IL, 60637, USA. david.satzer@uchospitals.edu.

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|July 6, 2019
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Precise stereotactic stem cell transplantation requires careful attention to injection techniques. This study evaluated CT-guided delivery in stroke patients, revealing deviations from target and factors influencing cell distribution.

Keywords:
Image guidanceIntraoperative CTStem cellStereotaxy

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Area of Science:

  • Neurosurgery
  • Regenerative Medicine
  • Medical Imaging

Background:

  • Stereotactic stem cell transplantation is increasingly used, but injection techniques lack detailed analysis.
  • Accurate delivery is crucial for deep brain targets.

Purpose of the Study:

  • To assess the precision of CT-guided stem cell delivery in patients with ischemic stroke.
  • To identify factors influencing cell distribution during stereotactic transplantation.

Main Methods:

  • Ten ischemic stroke patients received CT-guided stem cell transplantation along three tracts near the infarct.
  • Intraoperative air deposits and postoperative MRI fluid signals were mapped relative to target coordinates.

Main Results:

  • Air deposits averaged 4.5 mm from target, with a directional bias anteriorly and superiorly.
  • The injection tract apex was 2.8 mm from target, with no directional bias.
  • Air deposit location varied based on cannula trajectory relative to the stroke cavity.

Conclusions:

  • Precise stereotactic cell transplantation presents technical challenges.
  • Cell suspension reflux and injection tract characteristics impact delivery accuracy.
  • Intraoperative CT is valuable for assessing delivery and enabling trajectory adjustments.