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Piperine: role in prevention and progression of cancer

Mariia Zadorozhna1, Tiziana Tataranni2, Domenica Mangieri3

  • 1Department of Medical and Surgical Sciences, University of Foggia, Via Pinto 1, 71122, Foggia, Italy.

Molecular Biology Reports
|July 6, 2019
PubMed

Insights

Piperine, a natural compound from black pepper, shows promise as a chemopreventive agent against cancer. It may interfere with tumor development and progression without harming normal cells.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Cancer is a leading global cause of death, with current treatments having limitations.
  • Chemoprevention, using natural agents to prevent cancer, is an emerging strategy.
  • Piperine, an alkaloid from black pepper, has a history of medicinal use and potential anticancer properties.

Purpose of the Study:

  • To review the molecular and cellular mechanisms of piperine's chemopreventive action.
  • To explore piperine's potential in cancer prevention and treatment support.

Main Methods:

  • Literature review of studies on piperine's biological activities.
  • Analysis of research on piperine's effects on cancer cells and molecular pathways.

Main Results:

  • Piperine exhibits chemopreventive activities.
  • It interferes with tumorigenesis and metastasis.
  • Piperine demonstrates low cytotoxicity to normal cells at effective doses.

Conclusions:

  • Piperine is a promising natural compound for chemoprevention.
  • Further research into its mechanisms can support cancer prevention strategies.
  • Piperine may offer a safe and effective approach to complement cancer therapy.
Keywords:
Cancer therapyChemopreventionNatural compoundsPiperine

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