Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Enzymes

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...

Enzymes and Activation Energy

Enzymes and Activation Energy

The activation energy (or free energy of activation), abbreviated as Ea, is the small amount of energy input necessary for all chemical reactions to occur. During chemical reactions, certain chemical bonds break, and new ones form. For example, when a glucose molecule breaks down, bonds between the molecule's carbon atoms break. Since these are energy-storing bonds, they release energy when broken. However, the molecule must be somewhat contorted to get into a state that allows the bonds to...

Potential Energy

Potential Energy

The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Bioactive Side of Peas: Bio-functional Potential of Pea-Derived Ingredients on Cardiovascular Health.

Plant foods for human nutrition (Dordrecht, Netherlands)·2026

Same author

Multitarget Amaranth Peptides: ACE Inhibition, ACE2 Modulation, and Bioavailability Assessment.

Plant foods for human nutrition (Dordrecht, Netherlands)·2026

Same author

Antioxidant bioactivity of sunflower protein hydrolysates in Caco-2 cells and in silico structural properties.

Food chemistry·2025

Same author

Agronomic and Metabolic Responses of <i>Citrus clementina</i> to Long-Term Irrigation with Saline Reclaimed Water as Abiotic Factor.

International journal of molecular sciences·2025

Same author

Thermal Gelation of Proteins from Cajanus cajan Influenced by pH and Ionic Strength.

Plant foods for human nutrition (Dordrecht, Netherlands)·2023

Same author

Emulsifying Capacity of Cowpea Protein Isolates. Effect of Thermal and Hydrolytic Treatment.

Plant foods for human nutrition (Dordrecht, Netherlands)·2023

Search research articles

Related Experiment Video

Updated: Jan 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

Broken Rice as a Potential Functional Ingredient with Inhibitory Activity of Renin and Angiotensin-Converting

María Pinciroli¹, Paula Aphalo², Agustina E Nardo²

¹Programa Arroz, Facultad de Ciencias Agrarias y Forestales (FCAyF), Universidad Nacional de la Plata, 60 and 119 St. (1900), La Plata, Buenos Aires, Argentina.

Plant Foods for Human Nutrition (Dordrecht, Netherlands)

|July 6, 2019

Summary

Broken rice protein hydrolysate shows significant potential as a functional ingredient. This byproduct effectively inhibits key enzymes, suggesting health benefits for managing blood pressure.

Keywords:

ACE inhibitory peptides Broken rice Molecular docking analysis Renin inhibitory peptides

More Related Videos

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits

Published on: January 3, 2025

Repeatable Stair-step Assay to Access the Allelopathic Potential of Weedy Rice Oryza sativa ssp.

Repeatable Stair-step Assay to Access the Allelopathic Potential of Weedy Rice Oryza sativa ssp.

Published on: January 28, 2020

Related Experiment Videos

Last Updated: Jan 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits

Published on: January 3, 2025

Repeatable Stair-step Assay to Access the Allelopathic Potential of Weedy Rice Oryza sativa ssp.

Repeatable Stair-step Assay to Access the Allelopathic Potential of Weedy Rice Oryza sativa ssp.

Published on: January 28, 2020

Area of Science:

Food Science and Technology
Biochemistry
Nutraceuticals

Background:

Broken rice is an underutilized industrial byproduct.
Rice protein hydrolysates (RPH) may possess health-promoting properties.
Investigating RPH for functional and biological benefits is warranted.

Purpose of the Study:

To evaluate broken rice as a functional ingredient.
To analyze the antihypertensive potential of RPH from broken rice.
To identify specific peptides responsible for enzyme inhibition.

Main Methods:

Obtained RPH from a high-protein broken rice variety (Nutriar FCAyF).
Assessed angiotensin converting enzyme (ACE) and renin inhibition (IC50 values).
Purified RPH using gel permeation chromatography and RP-HPLC.
Analyzed the sequence of antihypertensive peptides in purified fractions.

Main Results:

RPH exhibited significant ACE and renin inhibitory activity (IC50 = 0.87 and 2.7 mg/mL, respectively).
Purified fractions contained peptides that interact with the active sites of ACE and renin.
Hydrolysis treatment enhanced the functional and biological properties of rice proteins.

Conclusions:

Hydrolyzed broken rice protein is a promising ingredient for functional foods.
RPH demonstrates potential for developing nutraceuticals targeting blood pressure management.
Utilizing rice industry byproducts like broken rice offers sustainable health solutions.