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Related Concept Videos

Binge Eating Disorders01:23

Binge Eating Disorders

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Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
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Intrinsically Disordered Proteins02:18

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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Disorders of Erythrocytes01:27

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
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Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Related Experiment Video

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A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
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Protocols Using Rodents to Model Eating Disorders in Humans.

Neil E Rowland1

  • 1Department of Psychology, University of Florida, Gainesville, FL, USA. nrowland@ufl.edu.

Methods in Molecular Biology (Clifton, N.J.)
|July 6, 2019
PubMed
Summary
This summary is machine-generated.

Animal models offer a cost-effective approach to studying eating disorders like anorexia nervosa and obesity. Rodent laboratory protocols can advance the understanding and treatment of these complex feeding dysfunctions.

Keywords:
Cost-based anorexiaDiet-induced obesityReflexive eatingStructured eating

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Area of Science:

  • Behavioral neuroscience
  • Animal models of human disease
  • Physiology

Background:

  • Dysfunctional feeding behavior presents bidirectionally: restricted eating (leading to anorexia nervosa) and overeating (leading to obesity and metabolic syndrome).
  • Both restricted and excessive eating patterns are challenging to prevent and treat effectively.
  • Animal models with translational validity are crucial for advancing research in human eating disorders.

Purpose of the Study:

  • To describe laboratory protocols using rodents for modeling human eating dysfunctions.
  • To provide a resource for researchers investigating the biological underpinnings of feeding behavior.

Main Methods:

  • Utilizes rodent models to simulate aspects of human eating disorders.
  • Details specific laboratory protocols for studying feeding behavior in rodents.
  • Focuses on creating models for both restricted and excessive food intake.

Main Results:

  • Presents established rodent protocols for modeling eating dysfunctions.
  • Highlights the utility of these models for translational research.
  • Provides a foundation for further investigation into the mechanisms of eating disorders.

Conclusions:

  • Rodent models offer a viable and cost-effective method for studying complex human eating disorders.
  • Laboratory protocols described can facilitate research into anorexia nervosa and obesity.
  • Advancing understanding through animal models is key to developing effective interventions.