Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipogenesis in developing human adipose tissue.

M Dunlop, J M Court

    Early Human Development
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Human fetal fat cells synthesize lipids early in development. This de novo fatty acid synthesis, crucial for lipid accumulation, increases with gestational age and is stimulated by insulin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Repeatability, reproducibility and normative ranges for EyeGuide Focus testing system in elite male rugby players.

    Journal of science and medicine in sport·2024
    Same author

    Experiences of hospice dementia care: A qualitative study of bereaved carers and hospice clinicians.

    PloS one·2023
    Same author

    Caregiver experiences of hospice dementia care: a systematic review and meta-ethnography.

    Aging & mental health·2023
    Same author

    The value of FDG positron emission tomography/computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation.

    Health technology assessment (Winchester, England)·2011
    Same author

    Sore spots between doctors and the press.

    Canadian family physician Medecin de famille canadien·2010
    Same author

    Steps for successful funding applications.

    Injury·2010
    Same journal

    Corrigendum to "2D:4D ratio, affective lability, and impulsivity in men with cannabinoid and methamphetamine use disorders: A comparative analysis with healthy controls" [Early Hum. Dev. Volume 221:106587(2026)].

    Early human development·2026
    Same journal

    Risk factors associated with the development of metabolic bone disease in infants admitted to the pediatric intensive care unit.

    Early human development·2026
    Same journal

    Association of cardiac perfusion index with cerebral regional oxygen saturation and fractional tissue oxygen extraction in preterm infants.

    Early human development·2026
    Same journal

    Long-term motor outcomes after parent-administered early physiotherapy in children born very preterm.

    Early human development·2026
    Same journal

    Second-to-fourth digit ratio in polycythemia vera: An exploratory anthropometric comparison with secondary polycythemia and healthy controls.

    Early human development·2026
    Same journal

    Infants who crawl while skin-to-skin in the first hour after birth are more likely to effectively breastfeed postpartum.

    Early human development·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Human Physiology

    Background:

    • Lipid synthesis is essential for adipose tissue development.
    • Understanding early lipogenesis in human fetuses is key to comprehending adipose tissue formation.

    Purpose of the Study:

    • To investigate de novo lipid synthesis in human fetal subcutaneous tissue.
    • To determine the role of insulin and acetyl-CoA carboxylase in fetal lipogenesis.

    Main Methods:

    • Assessing acetate incorporation into neutral lipids in fetal subcutaneous tissue.
    • Measuring acetyl-CoA carboxylase activity.
    • Quantifying tissue insulin levels and triglyceride content.

    Main Results:

    • De novo lipid synthesis was observed in early-stage human fetal subcutaneous cells.

    Related Experiment Videos

  • Lipogenic capacity and acetyl-CoA carboxylase activity increased with gestational age.
  • Insulin stimulated neutral lipid synthesis and was present from 16 weeks gestation, coinciding with rising triglyceride levels.

    • Conclusions:

    • De novo fatty acid synthesis is a primary mechanism for initiating lipid accumulation in developing human adipose cells.
    • Insulin plays a significant role in regulating fetal lipogenesis.
    • The findings highlight the dynamic process of adipose tissue development in utero.