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Isolation and genome sequences of two Feline Morbillivirus genotype 1 strains from Italy

Giulia Donato, Eliana De Luca, Paolo Emidio Crisi

  • 1National Reference Center for Whole Genome Sequencing of microbial pathogens: database and bioinformatic analysis, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Campo Boario, 64100, Teramo Italy. Tel.: +39 0861 332440, fax: +39 0861 332251,

Veterinaria Italiana
|July 6, 2019
PubMed

Insights

Feline morbillivirus (FeMV), a novel virus in cats, is being investigated for its role in kidney disease. This study reports the first full genome sequences of FeMV strains found in Italy.

Area of Science:

  • Veterinary Virology
  • Feline Infectious Diseases
  • Molecular Biology

Background:

  • Feline morbillivirus (FeMV) is a recently identified paramyxovirus in domestic cats.
  • The association between FeMV and tubulointerstitial nephritis in cats is suspected but not fully understood.
  • Limited genomic data exists for FeMV, hindering research into its pathogenesis.

Purpose of the Study:

  • To report the complete genome coding sequences of the first feline morbillivirus strains identified in Italy.
  • To provide foundational genomic data for future research on FeMV's role in feline kidney disease.
  • To contribute to the understanding of FeMV diversity and evolution.

Main Methods:

  • Isolation and sequencing of feline morbillivirus strains from affected cats in Italy.
  • Whole genome sequencing to obtain coding sequences.
  • Bioinformatic analysis of the obtained viral genomes.

Main Results:

  • The complete genome coding sequences of two distinct FeMV strains isolated in Italy were successfully determined.
  • These sequences represent the first full-length FeMV genomes reported from Italy.
  • The genomic data provides insights into the genetic makeup of circulating FeMV strains.

Conclusions:

  • The availability of these FeMV genome sequences facilitates further investigation into the virus's pathogenicity and epidemiology.
  • This study establishes a crucial genetic resource for understanding FeMV-associated diseases in cats.
  • Further research is warranted to elucidate the precise role of FeMV in feline tubulointerstitial nephritis.
Keywords:
Feline morbillivirusIsolationSequencing

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