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Sensory nerves protect from the progression of early stage osteoarthritis in mice

Yi-Jie Shao1,2, Xi Chen1, Zhi Chen1,2

  • 1Orthopedic Institute, Medical College, Soochow University , Suzhou, P.R. China.

Connective Tissue Research
|July 6, 2019
PubMed
Abstract

Insights

Sensory nerve loss accelerates early-stage osteoarthritis (OA) in mice, indicating that sensory nerves protect against OA progression. This highlights the protective role of sensory nerves in joint health.

Area of Science:

  • Biomedical science
  • Orthopedics
  • Neuroscience

Background:

  • Osteoarthritis (OA) is a chronic degenerative joint disease.
  • Sensory nerves influence bone metabolism and inflammation.
  • The role of sensory nerves in early OA progression is not fully understood.

Purpose of the Study:

  • To investigate the effect of sensory denervation on early-stage osteoarthritis (OA) in a mouse model.
  • To determine if sensory nerves play a protective or detrimental role in OA development.

Main Methods:

  • Osteoarthritis was induced using destabilization of the medial meniscus (DMM) in C57BL/6 mice.
  • Sensory denervation was achieved via subcutaneous capsaicin injection.
  • OA progression was assessed using micro-CT, histology, and RT-PCR.

Main Results:

  • Capsaicin successfully induced sensory denervation in the tibia.
  • Sensory denervation significantly increased Osteoarthritis Research Society International (OARSI) and synovitis scores.
  • Denervation led to decreased subchondral bone BV/TV and increased inflammatory factor expression.

Conclusions:

  • Sensory denervation accelerates early-stage OA progression in mice.
  • Sensory nerves appear to have a protective role against OA progression in the early stages.
Keywords:
Osteoarthritiscapsaicinmicro-CTsensory nervesubchondral bone

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