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Excess heart age in adult outpatients in routine HIV care

Angela M Thompson-Paul1, Frank J Palella2, Nabil Rayeed3

  • 1Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

AIDS (London, England)
|July 6, 2019
PubMed

Insights

Cardiovascular disease (CVD) risk is significantly higher in people with HIV (PLWH), with an "excess heart age" common even in early adulthood. Proactive management of CVD risk factors is crucial for aging PLWH.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a leading cause of illness and death in people with HIV (PLWH).
  • Estimating cardiovascular risk in PLWH is essential for timely intervention.

Purpose of the Study:

  • To estimate the
  • heart age
  • and
  • excess heart age
  • in people with HIV (PLWH) using individual cardiovascular risk factor profiles.

Main Methods:

  • Cross-sectional analysis of data from the HIV Outpatient Study (HOPS) including 2467 men and 619 women aged 30-74 years.
  • Calculated age- and race/ethnicity-adjusted heart age and excess heart age using a Framingham risk score-based model.

Main Results:

  • Adjusted excess heart age was 11.5 years in men and 13.1 years in women.
  • Excess heart age was observed across all age groups starting from 30-39 years, with the highest excess in the 50-59 age group.
  • Over 50% of participants had an excess heart age of at least 10 years.

Conclusions:

  • Elevated excess heart age is prevalent among PLWH, starting in early adulthood and affecting both sexes.
  • Early and proactive management of CVD risk factors is recommended for PLWH.
  • Routine use of heart age calculators can improve CVD risk stratification and guide interventions for aging PLWH.
Abstract

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