Bismuth-Catalyzed Synthesis of 2-Substituted Quinazolinones
Sandeep R Vemula1, Dinesh Kumar2, Gregory R Cook1
1Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58108-6050, USA.
Abstract:
The bismuth-catalyzed oxidative condensation of aldehydes with 2-aminobenzamide under aerobic conditions is reported using ethanol as the solvent. Good to excellent isolated yields (68-95%) of the corresponding 2-substituted quinazolinones were obtained under mild reaction conditions with excellent functional group tolerance. The quinazolinones were further functionalized to afford N-allylated quinazolinones, 2-aminopyridine derivatives, and annulated polyheterocyclic compounds via transition-metal catalyzed reactions.
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