Related Experiment Video
Updated: Jan 22, 2026
11:13
Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
11.6K
Visual mass-spec share (vMS-Share): a new public web-based mass spectrometry visualization and data mining
Niksa Blonder1, Benjamin C Orsburn2, Josip Blonder3
1Chemical Sciences Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8380, United States.
Journal of Proteomics & Bioinformatics
|July 6, 2019
Summary
Visual Mass-Spec Share (vMS-Share) is a new, free online resource for mass spectrometry data. It allows instant visualization and sharing of proteomics and metabolomics results with interactive search filters.
Area of Science:
- Biochemistry
- Computational Biology
- Data Science
Background:
- Mass spectrometry (MS) is crucial for proteomics and metabolomics.
- Sharing and visualizing MS data can be challenging.
- Existing platforms may lack integrated metadata and interactive visualization.
Purpose of the Study:
- Introduce Visual Mass-Spec Share (vMS-Share), a novel public MS data repository.
- Facilitate instant visualization and data mining of MS results.
- Optimize the sharing of proteomics and metabolomics experimental data.
Main Methods:
- Developed a web-based application for raw MS data visualization.
- Integrated display of metadata linked to experimental results.
- Implemented interactive search filters for user-friendly data exploration.
Main Results:
- vMS-Share provides free, public access to a mass spectrometry data repository.
- Enables instant visualization of raw MS data with associated metadata.
- Facilitates linking of MS identifications to experiments, peptides, and small molecules.
Conclusions:
- vMS-Share enhances the accessibility and usability of mass spectrometry data.
- The platform supports efficient data sharing and mining for proteomics and metabolomics.
- vMS-Share promotes collaborative research through its interactive visualization tools.
Related Concept Videos
01:21Tandem Mass Spectrometry
2.4K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
2.4K
01:19Mass Spectrometry: Overview
8.4K
Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...
8.4K
01:15Mass Spectrometry of Amines
5.3K
In mass spectroscopy, amines undergo fragmentation to give parent ions with odd molecule weights. This observed mass spectrum follows the nitrogen rule; a molecule with an odd number of nitrogen atoms produces a molecular ion with an odd molecular weight. Amines undergo fragmentation through α cleavage, producing nitrogen-containing cations—iminium ions—and alkyl radicals. Mass spectra of aromatic and cyclic aliphatic amines exhibit strong molecular ion peaks, but acyclic...
5.3K
01:13Mass Spectrometry: Isotope Effect
4.0K
Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of a molecule is different depending on the specific isotope of its elements involved. As a result, the mass spectrum of the molecule exhibits peaks from the same fragment at multiple positions. The positions of these mass signals depend on the mass differences between isotopes. Furthermore, the intensity of these signals is dependent on the...
4.0K
01:52Atomic Mass
69.7K
Atoms — and the protons, neutrons, and electrons that compose them — are extremely small. For example, a carbon atom weighs less than 2 × 10−23 g. When describing the properties of tiny objects such as atoms, we use appropriately small units of measure, such as the atomic mass unit (amu). The amu was originally defined based on hydrogen, the lightest element, then later in terms of oxygen. Since 1961, it has been defined with regard to the most abundant isotope of carbon, atoms of which...
69.7K
01:19MALDI-TOF Mass Spectrometry
6.6K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
6.6K