Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

38.3K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.3K
Regulated mRNA Transport02:22

Regulated mRNA Transport

6.9K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
6.9K
Epigenetic Regulation01:46

Epigenetic Regulation

33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
GTPases and their Regulation02:14

GTPases and their Regulation

9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.8K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

8.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
8.8K
Hormonal Regulation01:40

Hormonal Regulation

47.9K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Illness perceptions in stroke caregivers and their mediating role for caregiver burden, depression, and anxiety - a cross-sectional study.

Psychology, health & medicine·2025
Same author

On the non-inferiority of metacognitive therapy for OCD: Clarifying the methodology and rationale.

Journal of anxiety disorders·2025
Same author

Shame and disgust in patients with inflammatory skin diseases: a systematic review of psychological correlates and psychotherapeutic approaches.

Frontiers in medicine·2025
Same author

Posttraumatic growth after stroke: A longitudinal observational study.

Rehabilitation psychology·2025
Same author

Corrigendum to "Metacognitive therapy versus exposure and response prevention for obsessive-compulsive disorder - a non-inferiority randomized controlled trial" Journal of Anxiety Disorders (2024), Volume 104, June 2024, 102873.

Journal of anxiety disorders·2024
Same author

Once in Contact, Forever Contaminated! Introducing a Clinically Validated Imagery- and Video-Based Chain of Contagion Task for the Measurement of Disgust and Contamination Change in Experimental Research and Clinical Practice.

Behavior therapy·2024

Related Experiment Video

Updated: Jan 22, 2026

Transcranial Direct Current Stimulation tDCS in Mice
11:54

Transcranial Direct Current Stimulation tDCS in Mice

Published on: September 23, 2018

15.1K

Does Transcranial Direct Current Stimulation (tDCS) Improve Disgust Regulation Through Imagery Rescripting?

Jakob Fink1, Cornelia Exner1

  • 1Department of Clinical Psychology and Psychotherapy, University of Leipzig, Leipzig, Germany.

Frontiers in Human Neuroscience
|July 6, 2019
PubMed
Summary

Imagery rescripting effectively reduces disgust, but adding transcranial direct current stimulation (tDCS) did not enhance these effects in healthy volunteers. Further research is needed to explore brain stimulation for emotion regulation.

Keywords:
brain stimulationdisgustemotion regulationimagery rescriptingneuropsychological mechanismprefrontal cortextranscranial direct current stimulationvisual cortex

More Related Videos

Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

15.6K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K

Related Experiment Videos

Last Updated: Jan 22, 2026

Transcranial Direct Current Stimulation tDCS in Mice
11:54

Transcranial Direct Current Stimulation tDCS in Mice

Published on: September 23, 2018

15.1K
Transcranial Direct Current Stimulation tDCS for Memory Enhancement
10:37

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

15.6K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K

Area of Science:

  • Neuroscience
  • Psychology
  • Cognitive Science

Background:

  • Imagery rescripting (ImR) shows potential for reducing pathological disgust.
  • Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique used to support emotion regulation.
  • Previous studies indicated small effects of ImR on disgust reduction.

Purpose of the Study:

  • To investigate if tDCS can enhance the disgust-reducing effects of ImR.
  • To explore the neuropsychological mechanisms underlying imagery by comparing stimulation over the dorsolateral prefrontal cortex and visual cortex (VC).

Main Methods:

  • Fifty-eight healthy volunteers participated in a randomized controlled study.
  • Participants underwent ImR or a control condition, combined with either active or sham tDCS.
  • tDCS was applied over the dorsolateral prefrontal cortex or the visual cortex (VC).

Main Results:

  • Imagery rescripting (ImR) confirmed its effect in reducing disgust.
  • Supplementary transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex or visual cortex (VC) did not significantly improve disgust reduction compared to sham stimulation.
  • The study did not find evidence that tDCS enhances ImR's effectiveness in reducing disgust.

Conclusions:

  • While ImR is effective in reducing disgust, combining it with tDCS, regardless of stimulation site (dorsolateral prefrontal cortex or VC), did not yield enhanced outcomes in this study.
  • The findings suggest that current tDCS protocols may not be sufficient to augment ImR's emotion-regulation capabilities for disgust.