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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
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CXCR5+ CD8 T Cells: Protective or Pathogenic?

Kristen M Valentine1, Katrina K Hoyer2

  • 1Quantitative and Systems Biology Graduate Program, University of California, Merced, Merced, CA, United States.

Frontiers in Immunology
|July 6, 2019
PubMed

CD8 T cells are infrequently considered part of germinal center reactions. Yet, a distinct CXCR5+ CD8 T cell subset identified within the B cell follicle and germinal center in situations of chronic antigen has recently been defined. CXCR5+ CD8 T cells maintain transcriptional and phenotypic features consistent with the CD8 T cell nomenclature of a non-exhausted, effector memory population. CD8 T cell localization to the B cell follicle suggests a functional profile similar to CD4 T follicular helper cells that are licensed to promote B cell responses. The functional mechanisms defined under different immune settings, while largely similar, differentially control disease pathogenesis. CXCR5+ CD8 T cells control viral load during infection, and also promote antibody-mediated autoimmune disease progression. The existence of this novel CXCR5+ CD8 T cell subset in human and murine models of disease may provide a paradigm shift in our understanding of germinal center reactions.

Keywords:
B cell follicleCD8 T cellsautoimmune diseasecancerchronic viral infectiongerminal center

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