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New emerging targets in cancer immunotherapy: the role of TIM3

Alex Friedlaender1, Alfredo Addeo1, Giuseppe Banna2

  • 1Oncology, Hopitaux Universitaires de Geneve, Geneva, Switzerland.

ESMO Open
|July 6, 2019
PubMed

Insights

Immune-checkpoint inhibitors like PD-1/PD-L1 and CTLA-4 improve cancer treatment, but many patients still progress. Investigating new targets, such as T-cell immunoglobulin and mucin domain-3 (TIM-3), is crucial for advancing immuno-oncology.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Immune-checkpoint inhibitors targeting PD-1/PD-L1 and CTLA-4 have transformed cancer therapy.
  • Despite significant improvements, many cancer patients do not respond to current checkpoint inhibitors.
  • Combination therapies show promise but require further investigation.

Purpose of the Study:

  • To review the current landscape of immune-checkpoint inhibition in cancer therapy.
  • To highlight the limitations of existing treatments and the need for novel targets.
  • To discuss T-cell immunoglobulin and mucin domain-3 (TIM-3) as a promising next-generation immune-checkpoint target.

Main Methods:

  • Review of current literature on immune-checkpoint inhibitors.
  • Analysis of clinical trial outcomes for combination therapies.
  • Exploration of emerging immune-checkpoint targets, focusing on TIM-3.

Main Results:

  • Established checkpoint inhibitors (PD-1/PD-L1, CTLA-4) offer significant survival benefits for specific cancers.
  • Combination strategies are demonstrating encouraging results in melanoma, renal cell carcinoma, and non-small-cell lung cancer.
  • TIM-3 emerges as a key target with potential to overcome resistance and improve patient outcomes.

Conclusions:

  • Further research into novel immune-checkpoint targets like TIM-3 is essential for advancing immuno-oncology.
  • Overcoming resistance to current therapies through new targets could benefit a broader patient population.
  • TIM-3 represents a promising avenue for developing next-generation cancer immunotherapies.
Keywords:
TIM3immunotherapy

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