Successful Treatment With Omalizumab in a Child With Asthma and Urticaria: A Clinical Case Report

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Maria Maddalena Sirufo1,2, Lia Ginaldi1,2, Massimo De Martinis1,2

  • 1Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Frontiers in Pediatrics
|July 6, 2019
PubMed

Insights

Chronic spontaneous urticaria (CSU) in children often links to other conditions. While omalizumab is approved for adolescents and adults, its use in younger children (under 12) for CSU is off-label but beneficial for asthma control.

Area of Science:

  • Pediatric Dermatology
  • Allergology
  • Immunology

Background:

  • Childhood urticaria, particularly chronic spontaneous urticaria (CSU), is common but persistent cases are less frequent.
  • CSU in children frequently co-occurs with conditions like asthma, allergic rhinitis, and atopic dermatitis.
  • A family history of atopy is common in pediatric CSU patients.

Observation:

  • Current therapeutic strategies for pediatric CSU align with international guidelines for adult chronic urticaria.
  • Omalizumab is the recommended add-on therapy for CSU in adolescents (12+) and adults unresponsive to antihistamines.
  • In children aged 6 to <12, omalizumab is indicated as an add-on therapy to improve asthma control.

Findings:

  • The use of omalizumab for CSU in children under 12 is considered "off-label."
  • Despite off-label status, omalizumab shows potential as a valuable therapeutic option in this age group.
  • Evidence suggests omalizumab's efficacy in managing CSU symptoms and associated comorbidities in children.

Implications:

  • Further research is needed to establish definitive guidelines for off-label omalizumab use in pediatric CSU.
  • Clarifying the role of omalizumab in pediatric CSU could lead to improved treatment outcomes and quality of life.
  • This highlights the need for more evidence-based therapeutic options for managing CSU in younger children.

Keywords:
allergyasthmachildchronic spontaneous urticariahypersensitivityomalizumabprecision medicinetranslational medical research

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