Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lung Capacity

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Worldwide Impact of Human Development and Inequality on the Prevalence of Asthma, Rhinoconjunctivitis and Eczema. Global Asthma Network's Ecological Study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026

Same author

Dynamics of the Epigenome, Microbiome, and Metabolome in Relation to Early Adiposity in the Maternal-Infant Axis: Protocol for a Prospective, Observational Pilot Study in the Spanish NEMO Cohort.

Journal of clinical medicine·2025

Same author

Impact of environmental exposures on exhaled breath and lung function: NELA Birth Cohort.

ERJ open research·2025

Same author

Role of body mass index in unbalanced (dysanaptic) lung growth of healthy infants.

Pediatric pulmonology·2024

Same author

Pulmonary function and bronchopulmonary dysplasia classification: insights from the Spanish Registry.

European journal of pediatrics·2024

Same author

Severe Asthma and Biological Therapies: Now and the Future.

Journal of clinical medicine·2023

Search research articles

Related Experiment Video

Updated: Jan 22, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Early Lung Function and Future Asthma.

Manuel Sánchez-Solís^1,2,3

¹Department of Pediatric, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.

Frontiers in Pediatrics

|July 6, 2019

Summary

Childhood asthma may be linked to congenital airway characteristics or early airway remodeling. Further research is needed to identify early risk factors and develop interventions for asthma.

Keywords:

asthma asthma risk factors bronchial (airway) hyperresponsiveness lung function wheeze

More Related Videos

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Published on: August 9, 2024

Related Experiment Videos

Last Updated: Jan 22, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Published on: August 9, 2024

Area of Science:

Pediatric Pulmonology
Respiratory Medicine
Asthma Pathophysiology

Background:

Asthma is associated with reduced lung function, evident in childhood and persisting into adulthood.
The origins of impaired lung function in asthma—whether congenital or due to early airway remodeling—remain unclear.
Early life factors influencing asthma development and progression require further investigation.

Purpose of the Study:

To investigate the relationship between early lung function, congenital airway characteristics, and airway remodeling in childhood asthma.
To determine if impaired lung function is a risk factor for asthma development or a consequence of the disease.
To explore the role of early bronchial hyperresponsiveness (BHR) as a predictor of asthma, particularly in high-risk populations.

Main Methods:

Longitudinal assessment of lung function in children with persistent asthma.
Evaluation of airway remodeling markers in pediatric asthma patients.
Analysis of bronchial hyperresponsiveness (BHR) in infants and children, with a focus on offspring of asthmatic mothers.

Main Results:

Reduced lung function is observed in children with persistent asthma and continues into adulthood.
The exact timing and cause of lung function decline in asthma (congenital vs. acquired) are not definitively established.
Early BHR is common in infants but not consistently a predictor of later asthma, except possibly in offspring of asthmatic mothers.

Conclusions:

Understanding the early pathophysiology of asthma is crucial for identifying risk factors and developing targeted interventions.
More research is needed to clarify the role of congenital factors versus early airway remodeling in asthma development.
Identifying specific early risk factors, like BHR in high-risk infants, could lead to improved therapeutic strategies and altered disease trajectories.