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Primary hepatic lymphoma: A rare case report.

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Summary

Primary hepatic lymphoma (PHL), a rare non-Hodgkin's lymphoma, was diagnosed postoperatively in a patient presenting with abdominal pain. Treatment involved surgical resection followed by R-CHOP chemotherapy.

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Area of Science:

  • Hepatobiliary Malignancies
  • Hematologic Oncology

Background:

  • Primary hepatic lymphoma (PHL) is an exceptionally rare form of extranodal non-Hodgkin's lymphoma.
  • It often presents insidiously, leading to diagnostic challenges and potential delays in treatment.

Observation:

  • A patient presented with non-specific symptoms including abdominal pain, vomiting, anorexia, and weight loss, alongside hepatomegaly.
  • Preoperative investigations, including imaging, suggested a liver mass, but a definitive diagnosis via biopsy or FNAC was not obtained prior to surgery.
  • Contrast-enhanced computed tomography revealed a well-defined liver mass with specific imaging characteristics.

Findings:

  • The patient underwent a left hepatectomy with middle hepatic vein resection.
  • Postoperative histopathological examination confirmed the diagnosis of diffuse large B-cell lymphoma of the liver.

Implications:

  • This case highlights the importance of considering PHL in the differential diagnosis of liver masses, even with non-specific symptoms.
  • The successful treatment strategy involved surgical resection followed by a standard chemotherapy regimen (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone).
  • Early and accurate diagnosis is crucial for effective management and improved outcomes in PHL.