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Flow control for lateral flow strips with centrifugal microfluidics.

Daniel M Kainz1, Susanna M Früh2, Tobias Hutzenlaub2

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Centrifugal microfluidics enable precise flow control in lateral flow strips (LFSs), overcoming limitations of current designs for enhanced quantitative diagnostics. This method ensures complete sample passage through membranes, improving assay sensitivity and reliability.

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Area of Science:

  • Microfluidics
  • Biomedical Diagnostics
  • Analytical Chemistry

Background:

  • Lateral flow strips (LFSs) are crucial for rapid clinical diagnostics but face challenges in quantitative and sensitive measurements due to restricted flow control.
  • Existing LFS designs often exhibit limited control over fluid dynamics, impacting assay performance and reproducibility.
  • Integrating LFS membranes into microfluidic systems offers potential for improved performance, but requires effective flow management.

Purpose of the Study:

  • To develop a novel flow control mechanism for LFSs utilizing centrifugal microfluidics.
  • To demonstrate centrifugal force as a method for independent control of flow rate through LFS membranes.
  • To provide a guideline for integrating chromatographic membranes into centrifugal microfluidic disks to prevent bypass flow.

Main Methods:

  • Implementation of lateral flow membranes within centrifugal microfluidic cartridges.
  • Radial outward flow of sample liquid through the membrane, driven solely by centrifugal force.
  • Development and application of a formula to ensure complete sample elution through the membrane.

Main Results:

  • Achieved flow control independent of membrane properties (wetting, permeability) by using centrifugal force.
  • Demonstrated adjustable flow rates, enabling precise control over sample incubation times.
  • Verified the formula's effectiveness in preventing bypass flow across various membranes, flow rates, and sample viscosities.

Conclusions:

  • Centrifugal microfluidics provide a robust solution for flow control in LFSs, enhancing their quantitative and sensitive capabilities.
  • The developed method offers independence from membrane characteristics, simplifying assay design and improving reliability.
  • The derived formula serves as a valuable tool for the successful integration of LFS membranes into centrifugal microfluidic platforms.