Related Experiment Video

Updated: Jan 22, 2026

Orthotopic Mouse Model of Colorectal Cancer
08:43

Orthotopic Mouse Model of Colorectal Cancer

Published on: December 4, 2007

47.1K

Melatonin: An important anticancer agent in colorectal cancer

Mohammad Mirza-Aghazadeh-Attari1,2, Amir Mohammadzadeh1,2, Soroush Mostavafi1,2

  • 1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Cellular Physiology
|July 6, 2019
PubMed

Insights

Melatonin, a circadian rhythm hormone, shows promise in colorectal cancer treatment by regulating cell signaling pathways. This review explores its potential role in enhancing conventional therapies and its anticancer effects.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Colorectal cancer (CRC) is a prevalent malignancy, particularly in the elderly, but also occurs in younger individuals via hereditary syndromes.
  • Dysregulated cellular signaling pathways are central to CRC pathology.
  • Melatonin, a neuro-hormone crucial for circadian rhythm, modulates various signaling pathways.

Purpose of the Study:

  • To review the significance of melatonin in colorectal cancer.
  • To explore the potential clinical applications of melatonin in CRC treatment.

Main Methods:

  • Literature review of studies on melatonin and colorectal cancer.
  • Analysis of melatonin's effects on cellular signaling, immune function, and tumor microenvironment.
  • Examination of melatonin's role in apoptosis, proliferation, migration, and invasion.

Main Results:

  • Melatonin modulates key signaling pathways implicated in CRC.
  • It exhibits antioxidant properties and influences the tumor microenvironment and immune function.
  • Studies indicate melatonin can induce apoptosis, enhance sensitivity to chemotherapy and radiotherapy, and inhibit cancer cell proliferation, migration, and invasion.

Conclusions:

  • Melatonin demonstrates significant potential as an adjuvant therapy for colorectal cancer.
  • Further clinical research is warranted to establish its therapeutic efficacy and optimal use in CRC management.
Keywords:
apoptosiscolorectal cancermelatoninproliferationtumor progression

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.9K

Related Concept Videos

Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
544
Air-entraining Agents01:27

Air-entraining Agents

Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
260
Masking and Demasking Agents01:19

Masking and Demasking Agents

EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
3.5K
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
608
Spasmolytic Agents: Chemical Classification01:29

Spasmolytic Agents: Chemical Classification

Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
1.3K
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
771