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Evaluation of Rapid Diagnostic Tests for Assessment of Hepatitis B in Resource-Limited Settings

James S Leathers1, M Belen Pisano2, Viviana Re2

  • 1Department of Emergency Medicine, UC Davis School of Medicine, UC Davis Health, Sacramento, CA, US.

Annals of Global Health
|July 6, 2019
PubMed

Insights

Low-cost rapid diagnostic tests (RDTs) for Hepatitis B virus (HBV) infection show promise for global health. HBsAg and anti-HBeAb RDTs demonstrated high accuracy, aiding HBV diagnosis and management in resource-limited settings.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Global Health Diagnostics

Background:

  • Chronic Hepatitis B (HBV) is a leading cause of liver disease globally.
  • Resource-limited settings require accessible and affordable diagnostic tools for HBV.
  • Rapid diagnostic tests (RDTs) offer a potential solution for HBV screening and management.

Discussion:

  • This study evaluated the performance of several HBV RDTs across diverse geographical regions.
  • The focus was on assessing sensitivity and specificity for clinical utility.
  • Multicontinent evaluation ensures relevance for varied healthcare systems.

Key Insights:

  • Hepatitis B surface antigen (HBsAg) RDTs exhibited optimal sensitivity and specificity.
  • Anti-HBeAb RDTs demonstrated acceptable sensitivity and excellent specificity.
  • These RDTs are suitable for widespread screening and patient management.

Outlook:

  • Wider adoption of validated RDTs can improve HBV control strategies.
  • Further research may explore combination testing for enhanced diagnostic accuracy.
  • Integration of RDTs into primary healthcare can reduce HBV-related morbidity and mortality.

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