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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Pulmonary Tuberculosis III01:31

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Pulmonary Tuberculosis IV01:26

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Related Experiment Video

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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

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Tuberculosis and lung cancer.

Camilo Molina-Romero1, Oscar Arrieta1, Rogelio Hernández-Pando2

  • 1Unidad Funcional de Oncología Torácica y Laboratorio de Medicina Personalizada, Instituto Nacional de Cancerología. Mexico City, Mexico.

Salud Publica De Mexico
|July 6, 2019
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Summary

Pulmonary tuberculosis (Tb) may increase lung cancer (LC) risk. Mycobacterium tuberculosis (MTb) might promote cancer through chronic inflammation or DNA integration, warranting further research into these mechanisms.

Keywords:
EGFRepidemiologyinflammationlung cancertuberculosis

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Epidemiology

Background:

  • Pulmonary tuberculosis (Tb) is a significant global health concern.
  • Lung cancer (LC) is a leading cause of cancer mortality worldwide.
  • The co-occurrence of Tb and LC has been noted, particularly in specific geographic regions.

Purpose of the Study:

  • To review epidemiological studies on the association between lung cancer and pulmonary tuberculosis.
  • To explore potential molecular mechanisms linking Tb infection to LC development.

Main Methods:

  • Systematic review of research databases.
  • Inclusion of studies using keywords "lung cancer" and "pulmonary tuberculosis".

Main Results:

  • Epidemiological evidence, especially from Asian countries, suggests a link between Tb and LC.
  • Proposed mechanisms include chronic inflammation from Tb causing DNA damage in bronchial epithelium.
  • Bacterial DNA integration via lateral gene transfer from Mycobacterium tuberculosis (MTb) into bronchial cells is another hypothesis.

Conclusions:

  • A confirmed epidemiological relationship exists between lung cancer and pulmonary tuberculosis.
  • Mycobacterium tuberculosis may actively contribute to cellular transformation processes leading to cancer.
  • Further investigation is crucial to elucidate the precise molecular mechanisms involved.