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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Tuberculosis and lung cancer
Camilo Molina-Romero1, Oscar Arrieta1, Rogelio Hernández-Pando2
1Unidad Funcional de Oncología Torácica y Laboratorio de Medicina Personalizada, Instituto Nacional de Cancerología. Mexico City, Mexico.
Objective:
To describe the epidemiological studies about the relationship between lung cancer (LC) and pulmonary tuberculosis (Tb) and its possible molecular mechanisms.
Materials And Methods:
We reviewed research databases in search of publications that included keywords LC and Tb.
Results:
It has been proposed that chronic inflammation in the lungs due to Tb could cause clastogenic activity in the DNA of bronchial epithelium. Another possibility is lateral gene transfer; since Mycobacterium tuberculosis (MTb) is an intracellular organism, bacterial DNA could integrate to bronchial epithelial cells inducing neoplastic transformation.
Conclusions:
There are epidemiological reports, particularly from Asian countries, which confirm a relationship between LC and Tb. MTb could play an active role in cellular transformation and it is important to elucidate the mecha- nism involved.
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