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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
7.7K
Epigenetics in non-small cell lung carcinomas.
Irlanda Peralta-Arrieta1, Leonel Armas-López1, Joaquín Zúñiga2,3
1Unidad de Investigación en Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México. Tlalnepantla, Mexico.
Salud Publica De Mexico
|July 6, 2019
Summary
Epigenetic aberrations are key in non-small cell lung cancer (NSCLC) development and treatment resistance. Understanding these epigenetic changes is crucial for designing effective NSCLC therapies and personalized medicine.
Area of Science:
- Oncology
- Epigenetics
- Molecular Biology
Background:
- Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality.
- Epigenetic alterations play a significant role in cancer development and progression.
- Current therapeutic strategies for NSCLC often face challenges with resistance.
Purpose of the Study:
- To systematically review epigenetic aberrations in NSCLC.
- To identify epigenetic factors involved in NSCLC diagnosis, progression, and therapeutic response.
Main Methods:
- Systematic literature review.
- Focus on scientific literature concerning lung cancer epigenetics and NSCLC.
Main Results:
- Advances in epigenome studies reveal molecular complexes influencing tumorigenesis.
- Epigenetic mechanisms are implicated in NSCLC initiation, promotion, and progression.
- Epigenetic alterations contribute to NSCLC therapy resistance.
Conclusions:
- Epigenetic complexes and mechanisms are critical targets for novel NSCLC therapies.
- Integrated knowledge of epigenetics is fundamental for personalized lung cancer medicine.
- Further analysis of epigenetic factors will enhance therapeutic design.
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