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An apparent fatal valproic acid poisoning
Journal of Analytical Toxicology
|January 1, 1988
Summary
Fatal valproic acid poisoning is rare, with limited data on toxic levels. This case report details lethal valproic acid concentrations in tissues following a suicidal overdose, providing crucial reference data for forensic toxicology.
Area of Science:
- Forensic Toxicology
- Clinical Chemistry
- Pharmacology
Background:
- Limited data exists on toxic or fatal concentrations of valproic acid in biological samples.
- Accurate interpretation of post-mortem valproic acid levels is challenging due to this data scarcity.
Observation:
- A case of sudden death is presented, strongly suggesting suicidal poisoning by valproic acid (56.4 g dose).
- Valproic acid was quantified in post-mortem tissues using gas chromatography and confirmed by gas chromatography/mass spectrometry.
Findings:
- Post-mortem tissue concentrations: blood 720 mg/L, liver 800 mg/kg, stomach contents 1700 mg.
- Therapeutic concentrations of phenobarbitone and propoxyphene were also detected.
Implications:
- This case provides valuable reference concentrations for interpreting valproic acid toxicity in forensic investigations.
- Highlights the importance of comprehensive toxicological analysis in post-mortem cases with suspected drug overdose.