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A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
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Postmenopausal endometriosis, where are we now?

Camille Ladanyi1, Sarah Boyd, Peter Sticco

  • 1Department of Obstetrics and Gynecology, Erlanger Hospital, University of Tennessee College of Medicine, Chattanooga, Tennessee, USA.

Current Opinion in Obstetrics & Gynecology
|July 6, 2019
PubMed
Summary

Postmenopausal endometriosis, a condition affecting 2-5% of women after menopause, is linked to local estrogen production. Surgical excision and careful hormone replacement therapy are recommended for management.

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Area of Science:

  • Gynecology
  • Endocrinology
  • Pathophysiology

Background:

  • Postmenopausal endometriosis affects 2-5% of women after menopause.
  • Limited research exists on its prevalence, pathogenesis, and treatment.
  • Estrogen dependence is central to endometriosis, even in postmenopausal women.

Purpose of the Study:

  • Review current literature on postmenopausal endometriosis.
  • Inform clinical decision-making for this condition.
  • Identify novel treatment and management approaches.

Main Methods:

  • Literature review of postmenopausal endometriosis.
  • Analysis of studies on local estrogen biosynthesis.
  • Examination of treatment strategies and risk factors.

Main Results:

  • Endometriotic lesions may contain enzymes for local estrogen production.
  • This local estrogen may explain endometriosis in hypoestrogenic postmenopausal women.
  • Further research is needed to understand prevalence and pathogenesis.

Conclusions:

  • Surgical excision of endometriosis lesions is recommended.
  • Combined hormone replacement therapy (estrogen and progestin) is advised.
  • Histologic studies are crucial for future management and treatment planning.