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Risk factors for postoperative meningitis after microsurgery for vestibular schwannoma

Bowen Huang1, Yanming Ren1, Chenghong Wang1

  • 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.

Plos One
|July 6, 2019
PubMed
Abstract

Insights

Meningitis after vestibular schwannoma (VS) surgery is a serious risk. Advanced tumor grade (Koos grade IV), longer operations (>3 hours), and significant bleeding (≥400 ml) independently increase the risk of postoperative meningitis (POM).

Area of Science:

  • Neurosurgery
  • Otolaryngology
  • Infectious Disease

Background:

  • Meningitis is a severe complication following vestibular schwannoma (VS) microsurgery, leading to significant patient morbidity.
  • Limited research exists on the specific risk factors for meningitis post-VS surgery.

Purpose of the Study:

  • To identify and analyze the independent risk factors associated with postoperative meningitis (POM) after vestibular schwannoma (VS) microsurgery.

Main Methods:

  • Retrospective analysis of 410 VS patients undergoing microsurgery from June 2015 to November 2018.
  • Univariate and multivariate statistical analyses were employed to determine risk factors for POM.

Main Results:

  • Of 410 patients, 27 developed POM.
  • Univariate analysis identified hydrocephalus, Koos grade IV, operation duration > 3 hours, and intraoperative bleeding ≥ 400 ml as significant factors.
  • Multivariate analysis confirmed Koos grade IV, operation duration > 3 hours, and intraoperative bleeding ≥ 400 ml as independent risk factors for POM.

Conclusions:

  • Advanced tumor stage (Koos grade IV), prolonged operative duration (>3 hours), and substantial intraoperative blood loss (≥400 ml) are independent risk factors for POM.
  • Postoperative meningitis significantly prolongs hospital stay for VS patients.

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