Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

597
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
597
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

578
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
578
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

359
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
359
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

331
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
331
Kidney Structure01:45

Kidney Structure

75.0K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.0K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.0K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A quantitative rapid test for urine creatinine <i>via</i> Fenton's reaction and a self-driven microfluidic device.

Lab on a chip·2026
Same author

A microfluidic microspheres accumulation platform for direct visualization of urine albumin-to-creatinine ratio in patients with chronic kidney disease.

Biosensors & bioelectronics·2026
Same author

Universal Exit-Site Antibiotic Prophylaxis Reduces Exit-Site Infections in Pediatric Peritoneal Dialysis.

Kidney international reports·2025
Same author

Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care.

Kidney international reports·2025
Same author

Toxic microbiome and progression of chronic kidney disease: insights from a longitudinal CKD-microbiome study.

Gut·2025
Same author

A 30-year case study of local implementation of global guidelines for data-driven diabetes management starting with the Hong Kong Diabetes Register.

The Lancet regional health. Western Pacific·2025

Related Experiment Video

Updated: Jan 22, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

631

Mitochondrial dysfunction in diabetic kidney disease.

Pascal Zhongping Wei1, Cheuk Chun Szeto1

  • 1From Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 6, 2019
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction, driven by high blood sugar, significantly worsens diabetic kidney disease (DKD). Understanding these mechanisms is key to developing new treatments for DKD.

Keywords:
Diabetic nephropathyMitochondrial dysfunctionmtDNA.

More Related Videos

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
06:05

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Published on: March 9, 2022

4.4K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.3K

Related Experiment Videos

Last Updated: Jan 22, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

631
An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
06:05

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Published on: March 9, 2022

4.4K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.3K

Area of Science:

  • Nephrology
  • Mitochondrial Biology
  • Diabetology

Background:

  • Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease globally.
  • The precise mechanisms underlying DKD pathogenesis remain incompletely understood.
  • Mitochondrial dysfunction is increasingly recognized as a critical factor in DKD development and progression.

Purpose of the Study:

  • To explore the role of mitochondrial dysfunction in diabetic kidney disease.
  • To elucidate the cellular and molecular mechanisms linking hyperglycemia to kidney damage.
  • To identify potential biomarkers and therapeutic targets for DKD.

Main Methods:

  • Review of evidence linking mitochondrial dysfunction to DKD.
  • Analysis of the kidney's sensitivity to metabolic stress due to high oxygen consumption.
  • Examination of cellular pathways affected by hyperglycemia, including ROS production, apoptosis, and mitophagy.

Main Results:

  • High plasma glucose directly impairs renal tubular cells, causing metabolic and cellular dysfunction.
  • Key mechanisms include overproduction of reactive oxygen species (ROS), apoptosis activation, and defective mitophagy.
  • Mitochondrial injury affects various kidney cells, including tubular cells, podocytes, mesangial cells, and glomerular endothelial cells.
  • Urinary mitochondrial DNA (mtDNA) shows potential as a biomarker for DKD-related mitochondrial damage.

Conclusions:

  • Mitochondrial dysfunction is a central player in the progression of diabetic kidney disease.
  • Understanding these pathobiological mechanisms is crucial for developing novel therapeutic strategies.
  • Targeting mitochondrial dysfunction offers a promising avenue for future DKD treatments, though current pharmacologic options are limited.