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Updated: Jan 22, 2026
13:04
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
Published on: March 1, 2019
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Long noncoding RNA FEZF1-AS1 in human cancers.
Yuanshi Zhou1, Shuwan Xu1, Haoming Xia1
1Department of HPB Surgery, The 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu-ro, Harbin 150086, China.
Summary
The long noncoding RNA FEZF1-AS1 is frequently found in human cancers. This RNA molecule drives tumor growth and spread by sponging microRNAs, suggesting it could be a diagnostic biomarker or therapeutic target.
Area of Science:
- Molecular Biology
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are implicated in human tumorigenesis.
- Ectopic expression of FEZF1-AS1 is observed in various cancers, including colorectal, gastric, and hepatocellular carcinoma.
Purpose of the Study:
- To summarize the literature on FEZF1-AS1's role in cancer.
- To elucidate the mechanisms by which FEZF1-AS1 contributes to tumorigenesis and progression.
Main Methods:
- Literature review and synthesis of existing research on FEZF1-AS1.
- Analysis of FEZF1-AS1's involvement in competing endogenous RNA (ceRNA) networks.
- Investigation of FEZF1-AS1's association with clinical features and cellular processes in cancer.
Main Results:
- FEZF1-AS1 primarily functions as a ceRNA, sponging tumor-suppressive microRNAs (miRNAs).
- Aberrant FEZF1-AS1 expression correlates with clinical features in cancer patients.
- FEZF1-AS1 regulates key cancer hallmarks: proliferation, anti-apoptosis, invasion, and metastasis.
Conclusions:
- FEZF1-AS1 plays a significant role in cancer development and progression.
- FEZF1-AS1 presents potential as a diagnostic biomarker and therapeutic target for various cancers.
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