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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
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Updated: Jan 22, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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Inflammatory bowel disease - glycomics perspective.

Maja Hanić1, Irena Trbojević-Akmačić1, Gordan Lauc2

  • 1Genos Glycoscience Research Laboratory, Zagreb, Croatia.

Biochimica Et Biophysica Acta. General Subjects
|July 6, 2019
PubMed
Summary
This summary is machine-generated.

Glycosylation, the modification of proteins, plays a crucial role in inflammatory bowel disease (IBD) development. Understanding aberrant glycosylation offers potential for early IBD diagnosis and predicting treatment response.

Keywords:
Crohn's diseaseGlycomicsGlycosylationInflammatory bowel diseasePathogenesisUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Biochemistry

Background:

  • Inflammatory bowel disease (IBD) pathogenesis involves genetic, environmental, and immune factors.
  • Distinguishing between Crohn's disease (CD) and ulcerative colitis (UC) can be challenging, impacting diagnosis and treatment.
  • Aberrant glycosylation is implicated in the etiology and progression of IBD.

Purpose of the Study:

  • To review current knowledge of IBD pathophysiology.
  • To highlight the role of glycosylation in IBD pathogenesis and disease progression.
  • To explore glycosylation as a potential biomarker for IBD diagnosis and treatment response.

Main Methods:

  • This mini-review synthesizes existing research on IBD.
  • Focuses on recent findings regarding glycosylation's involvement in IBD.
  • Examines the functional impact of altered protein glycosylation in the intestinal environment.

Main Results:

  • Glycosylation patterns are altered in IBD.
  • Aberrant glycosylation affects key intestinal proteins, contributing to disease.
  • Glycans are vital for maintaining intestinal homeostasis; disruptions lead to IBD.

Conclusions:

  • Aberrant glycosylation is a significant factor in IBD etiology.
  • Glycosylation holds promise as a biomarker for early IBD detection.
  • Understanding glycosylation can aid in predicting patient response to therapy.