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An AIE active pyrene based fluorescent probe for selective sensing Hg2+ and imaging in live cells
Yaqin Wu1, Xiaoye Wen1, Zhefeng Fan1
1School of Chemistry and Material Science, Shanxi Normal University, Linfen 041004, PR China.
Abstract:
A novel fluorescence probe pyrene based derivatives (1) with aggregation induced emission (AIE) properties was synthesized by an easy procedure. The probe 1 was characterized by UV-vis, Fluorescent, NMR, MS, SEM etc. It displayed high sensitivity and selectivity to Hg2+ compared with other metal ions in H2O/DMF solvent and the detection limit was 4.2 × 10-7 M. Upon addition of Hg2+, the 1 - Hg2+ compound was formed with the formation of 2:1. More importantly, the probe exhibited very low cytotoxicity and strong fluorescence emission in live cells. This showed that the probe had potential applications for detection of Hg2+ in environment and biosystems.
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