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Published on: December 9, 2015
Potentially Inappropriate Prescribing and Potential Clinically Significant Drug-Drug Interactions in Older
Zorica Cvetković1, Aneta Perić2, Silva Dobrić3
1Military Pharmacy "Slavija", Central Pharmacy-Storage, Department for Military Health, 11000 Belgrade, Serbia. zokizoka@gmail.com.
Older outpatients with drug interactions were more likely to have potentially inappropriate prescriptions (PIP). Nearly 30% of these inappropriate medications were involved in drug interactions, highlighting a significant safety concern.
Area of Science:
- Geriatric Medicine
- Clinical Pharmacy
- Pharmacovigilance
Background:
- Potentially inappropriate prescribing (PIP) is a concern in older adults.
- Clinically significant drug-drug interactions (csDDIs) can exacerbate medication risks.
Purpose of the Study:
- To determine the prevalence of PIP using the Screening Tool of Older Person's potentially inappropriate Prescriptions (STOPP) criteria in older outpatients.
- To assess the association between PIP and potential csDDIs.
Main Methods:
- Cross-sectional study of 248 outpatients aged ≥65 years.
- Utilized STOPP criteria for PIP identification and Medscape's Drug Interaction Checker for csDDIs.
- Patients were grouped based on the presence or absence of csDDIs.
Main Results:
- PIP prevalence was significantly higher in patients with potential csDDIs (43 vs. 19).
- Common PIPs included PPIs, long-acting benzodiazepines, thiazide diuretics in gout patients, and therapeutic duplication.
- A correlation was found between the number of medications, PIMs, PIPs, and potential csDDIs.
Conclusions:
- Older outpatients with csDDIs had higher total and inappropriate drug prescriptions.
- Approximately 30% of potentially inappropriate medications (PIMs) were involved in potential csDDIs.
- Findings underscore the link between drug interactions and prescribing quality in elderly outpatients.
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