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Updated: Jan 22, 2026
10:37
Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
36.5K
Metabolic Plasticity and Epithelial-Mesenchymal Transition
Timothy M Thomson1,2, Cristina Balcells3,4, Marta Cascante3,5
1Department of Cell Biology, Molecular Biology Institute of Barcelona, Science Research Council, 08028 Barcelona, Spain. titbmc@ibmb.csic.es.
Journal of Clinical Medicine
|July 7, 2019
Summary
Epithelial-mesenchymal transition (EMT) involves metabolic changes that drive cell reprogramming. This review highlights how metabolites regulate EMT and epigenetic modifications like methylation and acetylation.
Area of Science:
- Cell Biology
- Developmental Biology
- Metabolic Regulation
Background:
- Epithelial-mesenchymal transition (EMT) is a fundamental process in development and disease.
- EMT involves significant transcriptional and phenotypic changes.
- Metabolites and co-factors influence transcription factors driving EMT.
Purpose of the Study:
- To review metabolic features enabling EMT.
- To discuss cellular adaptations to metabolic demands during EMT.
- To emphasize metabolic regulation of epigenetic modifications in EMT.
Main Methods:
- Literature review of developmental biology and cell metabolism.
- Analysis of signaling pathways and transcription factor regulation.
- Focus on metabolic control of epigenetic modifications (methylation, acetylation).
Main Results:
- Metabolic pathways are crucial for initiating and sustaining EMT.
- Cells adapt their metabolism to support mesenchymal phenotypes.
- Metabolic regulation of DNA methylation and histone acetylation impacts EMT.
Conclusions:
- Metabolism plays a critical role in regulating EMT.
- Targeting metabolic pathways could offer therapeutic strategies for EMT-related diseases.
- Understanding metabolic-epigenetic crosstalk is key to controlling EMT.
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