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Related Concept Videos

Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

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Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
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Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

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Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
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Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

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In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
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Cyclic Processes And Isolated Systems01:19

Cyclic Processes And Isolated Systems

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A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state. 
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
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Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

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Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
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Related Experiment Video

Updated: Jan 22, 2026

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
04:54

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Published on: January 17, 2017

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Cyclic Olefin Copolymer Microfluidic Devices for Forensic Applications.

Brigitte Bruijns1,2, Andrea Veciana3, Roald Tiggelaar4

  • 1Mesoscale Chemical Systems, MESA+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7500 AE Enschede, The Netherlands. b.b.bruijns@utwente.nl.

Biosensors
|July 7, 2019
PubMed
Summary
This summary is machine-generated.

Cyclic olefin copolymer (COC) is a versatile material for forensic lab-on-a-chip (LOC) devices. COC enables rapid on-site testing, including presumptive substance identification and DNA amplification, enhancing forensic capabilities.

Keywords:
UV-VIS spectroscopycyclic olefin copolymerforensic scienceillicit drug analysismicrofluidic devicepolymer bondingpolymer surface functionalizationpresumptive forensic test

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Last Updated: Jan 22, 2026

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Thermal Measurement Techniques in Analytical Microfluidic Devices
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Thermal Measurement Techniques in Analytical Microfluidic Devices

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Area of Science:

  • Forensic Science
  • Materials Science
  • Analytical Chemistry

Background:

  • Microfluidic devices offer advantages for rapid forensic analysis at crime scenes.
  • Forensic applications demand microfluidic materials with biochemical compatibility, optical transparency, and chemical resistance.
  • Cyclic olefin copolymer (COC) possesses properties suitable for developing advanced forensic microfluidic systems.

Purpose of the Study:

  • To explore the versatility of cyclic olefin copolymer (COC) for lab-on-a-chip (LOC) systems in forensic applications.
  • To evaluate COC's suitability for on-chip presumptive color tests and DNA amplification reactions.

Main Methods:

  • Investigated chemical resistance and optical transparency of COC for on-chip presumptive color tests using absorption spectroscopy.
  • Verified COC compatibility with DNA amplification by performing on-chip multiple displacement amplification (MDA) reactions.

Main Results:

  • COC demonstrated suitable chemical resistance and optical transparency for developing on-chip presumptive color tests.
  • COC proved compatible with on-chip multiple displacement amplification (MDA) reactions, indicating its utility for forensic DNA analysis.

Conclusions:

  • Cyclic olefin copolymer (COC) is a promising material for developing novel microfluidic devices for forensic applications.
  • COC facilitates the creation of integrated lab-on-a-chip systems for rapid on-site forensic analysis, including presumptive substance identification and DNA amplification.