Related Experiment Video
Updated: Jan 22, 2026
08:40
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
Published on: August 1, 2013
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B cell maturation antigen (BCMA)-based immunotherapy for multiple myeloma.
Yu-Tzu Tai1, Kenneth C Anderson1
1LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School , Boston , MA , USA.
Expert Opinion on Biological Therapy
|July 7, 2019
Summary
B cell maturation antigen (BCMA) is a promising target for multiple myeloma (MM) immunotherapy. BCMA-targeted therapies, including ADCs and CAR T-cells, show significant efficacy in relapsed/refractory MM patients.
Area of Science:
- Oncology
- Immunotherapy
- Hematology
Background:
- B cell maturation antigen (BCMA) plays a key role in multiple myeloma (MM) pathophysiology.
- BCMA is a highly selective target antigen for novel MM immunotherapies.
Purpose of the Study:
- To review the immunobiological rationale for targeting BCMA in MM.
- To summarize preclinical and clinical data on BCMA-targeted therapies in MM.
- To discuss the efficacy, safety, and future directions of BCMA-targeted treatments.
Main Methods:
- Review of preclinical studies and recent Phase I/II clinical trials.
- Analysis of immunobiological rationale for BCMA targeting.
- Evaluation of clinical data on efficacy and safety of BCMA-targeted therapies.
Main Results:
- BCMA-targeted therapies (ADCs, CAR T, BiTEs) demonstrate significant efficacy in heavily pretreated MM patients.
- High response rates observed with BCMA-targeted monotherapies in relapsed and refractory MM.
- BCMA is the most selective antigen target for MM.
Conclusions:
- BCMA-targeted immunotherapies offer a transformative approach to MM treatment.
- Further research is needed to understand resistance mechanisms and optimize combination strategies.
- BCMA-based therapies hold promise for long-term disease control and potential cure in MM.
Keywords:
B cell maturation antigen (BCMA)Multiple myeloma (MM)adoptive T cell therapyantibody-drug conjugate (ADC)bi-specific T cell engager (BiTE)bone marrow (BM) microenvironmentcancer vaccinechimeric antigen receptor T cell (CAR T)minimal residual disease (MRD)monoclonal antibody (mAb)targeted immunotherapy
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